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甲氧化物颗粒的细胞毒性效应在体外采用不同的反应温度以热水合成

W M Md Saad¹, N A Mohd Noor², N S Mohamad Salin²

¹Universiti Teknologi MARA, Faculty of Health Sciences, Centre of Medical Laboratory Technology, Puncak Alam Campus, Selangor, Malaysia. wanmaz755@uitm.edu.my.

The Medical journal of Malaysia

|March 31, 2024

概括

在更高的温度下合成的氧化 (Bi2O3) 颗粒显示肝细胞中毒性降低,表明作为更安全的医学成像对比剂的潜力. 需要进一步的研究来评估危害和提高生物相容性.

科学领域:

纳米材料科学科学纳米材料科学
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

由于高X射线衰减,氧化物 (Bi2O3) 颗粒被探索用于医学成像.
生物相容性和体内稳定性的挑战阻碍了石化合物的开发.
生物二氧化碳 (Bi2O3) 具有作为基对比介质的替代品的潜力.

研究的目的:

描述在不同温度 (60,90,120°C) 中合成的Bi2O3颗粒.
研究Chang肝细胞中Bi2O3颗粒的细胞毒性.
评估合成温度对Bi2O3粒子特性和生物相容性的影响.

主要方法:

在60,90和120°C的水热合成Bi2O3颗粒.
细胞毒性测定包括细胞活力,形态和反应性氧物种 (ROS) 生产.
细胞内膜网膜 (ER) 压力基因的实时PCR分析 (GRP78,CHOP).

主要成果:

颗粒大小随着合成温度的增加而增加;较大的颗粒具有较低的细胞毒性.
随着粒子大小的增加,观察到GRP78和CHOP mRNA表达的下调.
在120°C合成的Bi2O3颗粒与相比,其毒性较低.

结论:

肝细胞对Bi2O3细胞毒性的反应与合成温度有关.
这些发现对于评估Bi2O3作为新型对比剂的危险性至关重要.
控制合成可以提高Bi2O3颗粒的生物相容性.

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