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Deniz Önal¹, Hilal Korkmaz², Gizem Önal³

¹Faculty of Medicine, Department of Physiology, Balıkesir University, Balıkesir, Türkiye.

|March 31, 2024

概括

高脂肪饮食加剧了老鼠的压力反应,减少了氧化.

科学领域:

神经内分泌学神经内分泌学
行为神经科学行为神经科学
肥胖问题研究研究

背景情况:

压力显著影响生理功能,包括食欲和体重.
催产素在控制压力和肥胖方面发挥着至关重要的作用.
高脂肪饮食 (HFD) 可以改变压力系统的反应.

研究的目的:

为了研究鼻内催产素对受压力反应的影响,在食对照或HFD的老鼠中进行了研究.
检查HFD如何影响催产素在调节压力和焦虑方面的有效性.

主要方法:

雄性Sprague-Dawley大鼠被养为对照或HFD6周.
慢性冷静化压力应用了5天.
动物接受了催产素或安慰剂的鼻内注射.
使用皮质醇水平和升高加迷宫测试来测量压力反应.
分析了前额叶皮和下丘脑中的催产素受体 (OxtR) 表达.

主要成果:

与对照大鼠相比,HFD养的老鼠表现出较高的压力反应.
催产素在对照大鼠中表现出抗焦虑作用,但在HFD养大鼠中没有.
在HFD养和/或接受催产素治疗的老鼠中,下丘脑OxtR表达增加.
前额叶皮层的OxtR水平在饮食或催产素治疗后保持不变.

结论:

体重会影响催产素的外围和中心作用.
肥胖可能会通过加强中央催产素受体信号传递来掩盖催产素的抗焦虑作用.
了解催产素的中心机制是解决压力和肥胖问题的关键.

关键词:

中央催产素受体的受体慢性压力是一种慢性压力.饮食引起的肥胖症饮食引起的肥胖症氧化素是一种氧化素.

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