药物诱导的过敏反应在巨细胞瘤中不常见:来自两个大型队列的研究结果
Michiel Beyens1, Vito Sabato1, Didier G Ebo1
1Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Immunology, Allergology, Rheumatology, Edegem, University Hospital Antwerp, Antwerp, Belgium.
The journal of allergy and clinical immunology. In practice
|March 31, 2024
概括
患有巨细胞瘤的患者患有严重药物诱导过敏反应 (DIA) 的风险更高,NSAID是最常见的触发因素. 建议对这些患者进行彻底的过敏检查.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 血液学 血液学 血液学
背景情况:
- 乳腺细胞瘤经常与过敏反应有关,特别是对海门虫的毒素.
- 这引发了人们对乳腺细胞瘤患者对药物诱导过敏反应 (DIA) 的敏感性增加的担忧.
- 之前对乳腺细胞瘤中DIA的系统调查缺乏.
研究的目的:
- 为了确定药物诱导性过敏反应 (DIA) 的患病率和临床特征,在患有巨细胞瘤的患者中.
- 评估这个人群中对各种药物类别的过敏反应的风险和特征.
主要方法:
- 一项追溯性研究,涉及470名来自两个参考中心的成年患者,他们已证实克隆性芽细胞疾病.
- 对所有参与者进行了全面的过敏检查,包括评估报告的药物过敏症.
主要成果:
- 药物过敏反应的患病率为6.3%,占所有药物过敏反应的三分之一.
- 非类固醇抗炎药物 (NSAIDs) 是最常见的原因 (56%),其次是术前药物 (23%) 和抗生素 (13%).
- 过敏反应严重,有43%的人经历了低血压昏迷;所有反应都是在乳腺细胞瘤诊断之前发生的.
结论:
- 药物诱导的过敏反应 (DIA) 在巨细胞瘤的患病率高于一般人群,但仍然很低.
- 巨细胞瘤患者的反应往往更严重.
- 建议对前期药物反应的乳腺细胞瘤患者进行彻底的过敏评估;随后可以安全地使用耐受良好的药物.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
288
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
288
Allergic Reactions
27.3K
Overview
27.3K
Allergic Drug Reactions
839
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
839
Hypersensitivities
626
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
626
Cross-reactivity
31.1K
Overview
31.1K
Desensitization and Tachyphylaxis
1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K


