鲁,一种被广泛消费的黄类化合物,通常会诱导催眠效应
Edward J Calabrese1, Peter Pressman2, A Wallace Hayes3
1School of Public Health and Health Sciences, Department of Environmental Health, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, USA.
概括
鲁丁是一种广泛消费的黄类化合物,在许多生物系统中表现出高的剂量反应. 然而,人类的低生物可用性限制了体外观察到的最佳益处,影响了临床应用.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 鲁丁是水果和蔬菜中普遍存在的黄类化合物,被广泛消费,并可作为食补充剂供应.
- 由于其在生物医学文献中报告的多系统化学预防性质,消费者对鲁丁的兴趣很高.
研究的目的:
- 为了提供第一次评估素诱导的度/剂量反应.
- 为了分析量化特征,机械基础,和影响的鲁丁的hormetic效应.
- 评估这些发现的生物,生物医学,临床和公共卫生相关性.
主要方法:
- 审查和综合现有的文献,对rutin的剂量反应效应的影响.
- 分析来自各种生物模型和细胞类型的数据.
- 在人体生物可用性背景下对体外发现的评估.
主要成果:
- 常规诱导的激素剂量反应很普遍,在众多生物模型和细胞类型中观察到不同的终点.
- 在体外研究中证明的最佳抑制作用目前无法在人类群体中实现.
- 鲁丁的低胃肠道生物可用性是人类疗效的关键限制因素.
结论:
- 鲁丁具有广泛的荷尔蒙剂量反应效应,具有显著的生物学和潜在的生物医学影响.
- 对于将体外益处转化为临床实践来说,鲁丁在人类中的低生物可用性是一个挑战.
- 未来对鲁丁的实验研究应该仔细考虑研究设计参数,特别是关于生物可用性和剂量优化.
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