积极的时间是血液感染患者死亡的风险因素:基于人口的队列队列
Kevin B Laupland1, Felicity Edwards2, Zoe Dettrick2
1Queensland University of Technology (QUT), Faculty of Health, Brisbane, Queensland, Australia; Department of Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
概括
血液培养中较短的阳性时间 (TTP),表明细菌生长速度更快,与患有血流感染 (BSI) 患者的死亡风险增加有关. 这一发现凸显了TTP作为BSI患者结果的关键因素.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 关于血液培养的时间到阳性 (TTP) 作为死亡风险因素,存在相互矛盾的证据.
- 血流感染 (BSI) 是一个重要的公共卫生问题,结果各不相同.
研究的目的:
- 在基于人口的BSI队列中调查TTP和30天全因病例死亡率之间的关联.
- 确定TTP是否是BSI患者死亡率的独立预测因素.
主要方法:
- 澳大利亚昆士兰州88,314名发生单微生物BSI患者的回顾性队列研究 (2000-2019).
- 来自全州医疗保健来源的临床,TTP和死亡率信息的数据链接.
- 统计分析根据年龄,性别,发病,并发症和感染重点进行调整.
主要成果:
- 平均TTP为14小时;第一个四分位数 (≤10小时) 与死亡风险显著增加有关 (OR 1.43).
- 这种关联在各种BSI病因方面持续存在,包括黄金葡萄球菌,肺炎链球菌和大肠杆菌.
- 在TTP中,BSI致病原体的显著变化被证明.
结论:
- 阳性反应的时间是诊断出血流感染的患者死亡率的重要决定因素.
- 早期发现BSI和及时干预可能对改善患者存活率至关重要.
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