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[用于qNMR测量的高纯度溶剂]

Yasuhiro Muto¹, Toru Miura¹, Yoshiaki Iwamoto¹

¹FUJIFILM Wako Pure Chemical Corporation.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

|March 31, 2024

概括

溶剂质量显著影响定量NMR (qNMR) 的准确性. 溶剂中的杂质,含水量和化比可以导致qNMR分析的不准确结果.

科学领域:

分析化学分析化学
频谱学是一种光谱学.

背景情况:

定量NMR (qNMR) 是主要药典 (JP,USP) 和ISO标准采用的可靠和高效的分析技术.
qNMR通过整合相对于参考标准的分析信号来量化组件.
现代的NMR仪器具有高分辨率和灵敏度,能够检测微量杂质.

研究的目的:

研究溶剂质量对定量NMR (qNMR) 精度的影响.
确定影响qNMR结果的关键溶剂参数,特别是有机杂质,含水量和化比.

主要方法:

通过执行空白溶剂试验来评估有机杂质的影响,以检测信号与分析物的重叠.
评估了水含量和度比对光谱灵敏度和信号对噪声 (S/N) 比的影响.
使用现代高分辨率,高灵敏度的NMR仪器.

主要成果:

有机杂质与分析剂信号的重叠信号直接导致信号整合不准确和错误的qNMR结果.
高含水量和低度比降低了检测灵敏度,因此降低了信号与噪声 (S/N) 比率.
这些因素需要仔细考虑,以获得准确的qNMR测量.

结论:

溶剂质量是影响定量NMR (qNMR) 分析准确性的关键因素.
控制有机杂质,水含量和溶剂中的化比对于可靠的qNMR量化至关重要.
遵守这些参数可确保qNMR数据的完整性和精度.

关键词:

脱的溶剂是一种脱溶剂.代度是指代的程度.定量的NMR是指NMR的数量.

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