在癌症的支持性护理中使用的药物与衰老相关的考虑
Darren J Walsh1, Michelle O'Driscoll2, Laura J Sahm3
1Pharmacy Department, University Hospital Waterford, Waterford, Ireland; Oncology Department, University Hospital Waterford, Waterford, Ireland; Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, Cork, Ireland.
Journal of geriatric oncology
|March 31, 2024
概括
综合老年学评估 (CGA) 改善了接受全身抗癌疗法 (SACT) 的癌症患者的生活质量. 本综述检查了老年人支持性护理药物的不良药物事件,突出了与年龄有关的变化和处方考虑因素.
科学领域:
- 老年瘤学 老年瘤学
- 临床药理学 临床药理学
- 癌症支持性护理 癌症支持性护理
背景情况:
- 综合老年学评估 (CGA) 改善了生活质量,并减少了接受全身抗癌疗法 (SACT) 的患者的毒性.
- 在接受SACT的老年人中,从支持性护理药物中获得不良药物事件 (ADEs) 的数据有限.
- 老年人通常在药理动力学和药理动力学研究中表现不足,这会影响药物安全性.
研究的目的:
- 审查影响辅助护理药物的药理动力学和药理动力学的与年龄相关的变化.
- 讨论癌症老年人的支持性护理药物的处方考虑因素.
- 为这个人群中常用的支持性护理药物提供建议.
主要方法:
- 与衰老相关的药理动力学和药理动力学变化的文献综述.
- 对影响老年癌症患者药物处方的因素的分析,包括多药和药物相互作用.
- 对支持性护理药物使用的建议的综合.
主要成果:
- 衰老会改变药物的吸收,分布,新陈代谢和分泌,影响药物的疗效和毒性.
- 多药性,可能不合适的药物和抗胆固醇负担是癌症老年人的重大问题.
- 为管理这个人口群体中常见的支持性护理药物提供了具体建议.
结论:
- 在患有癌症的老年人中优化支持性护理药物使用需要仔细考虑与年龄相关的生理变化.
- 解决多药和药物相互作用对于提高安全性和生活质量至关重要.
- 需要进一步的研究,以充分阐明CGA对支持性护理药物的ADE的影响.
更多相关视频
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
10.3K
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.1K
相关概念视频
01:27Nursing Ethical Principles II
958
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
958
01:21Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
01:15Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:28Drug Therapy
43
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
43
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K