急性相反应剂orosomucoid-2直接促进类风湿性炎症的发生
Ki-Myo Kim1,2, Kang-Gu Lee1,2, Saseong Lee1
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, South Korea.
Experimental & molecular medicine
|March 31, 2024
概括
一种急性阶段蛋白质ORM2 (Orosomucoid-2) 在类风湿性关节炎 (RA) 中被上调,并通过增加亲炎性介质来促进炎症. 这一发现表明ORM2是RA的潜在治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 类风湿病学 类风湿病学
背景情况:
- 在慢性炎症疾病中缺乏急性阶段蛋白质的系统分析.
- 在风湿性关节炎 (RA) 患者中,Orosomucoid-2 (ORM2) 被通过全球蛋白质组分析确定为高度差异表达的蛋白质.
研究的目的:
- 调查ORM2在类风湿性关节炎发病过程中的作用.
- 为了确定ORM2是否积极参与类风湿性炎症.
主要方法:
- 从RA患者的血清和尿液的全球蛋白质组概况.
- 在突液和膜中分析ORM2表达.
- 在RA巨细胞和纤维细胞样同胞细胞 (FLS) 上使用重组ORM2的体外研究.
- 在体内研究,包括ORM2在小鼠的关节内注射.
主要成果:
- 在RA突流体和膜中,ORM2表达显著上调,主要由突巨细胞和FLSs产生.
- 再组合ORM2通过NF-κB和p38 MAPK通路刺激了关键炎症性细胞因子 (IL-6,TNF-α,CXCL8,CCL2) 的产生.
- 甘氨酸C被确定为ORM2.2的受体.
- 在小鼠中,关节内ORM2注射加剧了关节炎的严重程度和巨细胞的透.
- 循环ORM2水平与RA疾病活性和放射性进展相关.
结论:
- 急性阶段蛋白ORM2直接促进炎症并加剧关节炎.
- 在类风湿性炎症中,ORM2起着积极的作用.
- ORM2代表了类风湿性关节炎的潜在新型治疗标.
相关概念视频
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K


