阐明中枢神经系统动脉静脉形缺陷背后的发病原因:一个图书识别分析
Maria D Astudillo Potes1,2,3, Megan M J Bauman1,2, Ali Shoushtari2
1Mayo Clinic Alix School of Medicine, Rochester, Minnesota, USA.
Neurosurgical review
|March 31, 2024
概括
图书统计分析揭示了动脉静脉形 (AVM) 发病因的不断发展的研究. 尽管在临床方面取得了进展,但AVM的确切遗传基础和病理生理机制仍然不清楚,需要进一步的基因研究.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 血管生物学 血管生物学
背景情况:
- 动脉静脉形 (AVMs) 是中枢神经系统 (CNS) 的复杂血管异常.
- 导致AVM形成的精确病理生理机制尚未完全阐明.
- 了解AVM的发病因子对于开发有效的治疗策略至关重要.
研究的目的:
- 进行关于AVM病变的高度引用文献的文献分析.
- 绘制研究趋势的演变图,并确定AVM研究的重点领域.
- 提供AVM研究的历史发展和当前景观的概述.
主要方法:
- 在科学网络数据库中进行了全面的搜索.
- 选择了100篇最多引用的关于AVM病变的文章.
- 分析了包括出版年份,文章类型,作者数量,期刊影响因子和原产国在内的文献计量参数.
主要成果:
- 分析包括1863篇文章,根据引用数量选择了前100篇.
- 研究组成包括24%的基础科学,46%的临床和30%的评论文章.
- 美国占主导地位的贡献 (约. 70%),随着时间的推移,VEGF和RAS/MAPK途径被确定为遗传研究的关键领域.
结论:
- 关于AVM基因组学和病变的研究兴趣明显增加.
- 虽然临床方面和风险因素得到了更好的理解,但AVM的基本遗传基础和病理生理机制需要进一步探索.
- 识别参与AVM病变的关键基因可能会揭示未来干预的潜在治疗点.
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