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在 Fe-N-C 单原子材料中,S-Doping 调控的铁状态为在中性pH下增强过氧化酶模仿活性

Fuying Zhu¹, YueYi Yu¹, Zhixuan Yu¹

¹School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|March 31, 2024

概括

研究人员开发了一种新的硫合铁单原子纳米材料 (Fe1@CN-S),在中性pH下表现出高过氧化酶类活性. 这一突破使得在生理条件下能够敏感和选择性地检测葡萄糖.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物化学生物化学

背景情况:

在中性pH下设计具有过氧化酶 (POD) 类活性的仿生纳米材料具有挑战性.
现有的催化剂通常需要特定的pH条件,限制了它们的应用.

研究的目的:

在中性pH下开发一种具有增强POD类活性的新型纳米材料.
研究基于铁的单原子纳米材料的结构-活性关系.

主要方法:

通过使用S-doping策略合成了一种硫合的铁单原子纳米材料 (Fe1@CN-S).
研究了POD类活动的机制,包括基质相互作用和旋转状态变化.
开发了一种在pH 7.的葡萄糖的单视觉检测方法.

主要成果:

在中性pH下,Fe1@CN-S表现出高的POD类活性.
通过旋转状态转换 (MS FeII到LS FeII),S-doping促进了TMB解离和OH*脱离.
LS FeII 位点与 H2O2 的相互作用增强,促进了催化活性.
在pH 7. 达到高度选择性和敏感的视觉葡萄糖检测.

结论:

在中性pH下,S-doping策略有效地增强铁单原子纳米材料的POD类活性.
Fe1@CN-S代表了在生理条件下开发敏感生物传感器的有希望的平台.
这项工作提供了一种新的方法,通过调节活性站点结构来设计高效的仿生催化剂.

关键词:

生物传感器生物传感器不同原子的兴奋剂.铁的单个原子是一个铁原子.过氧化酶的使用旋转状态调节旋转状态调节

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