简斯ACSP纳米粒子用于协同化学动力学疗法和放射敏感化
Mingzhen Xu1,2,3,4, Yuyi Qian4, Xinyi Li4
1Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai 201315, China.
ACS applied materials & interfaces
|April 1, 2024
概括
这项研究引入了一种用于癌症治疗的新型纳米粒子,通过产生反应性氧物种来增强放射治疗,以克服瘤的放射电阻并促进细胞死亡. 这种方法可以提高治疗效率,同时尽量减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤的放射性耐药性是放射治疗中的一个主要挑战,通常与保护性自和DNA修复机制有关.
- 低毒瘤和正常组织的副作用需要改进放射治疗策略和放射敏感剂.
研究的目的:
- 开发一个用于联合化学动力学治疗和放射敏感化的Janus纳米粒子.
- 通过操纵瘤微环境和细胞循环来克服瘤的放射电阻.
主要方法:
- 一个Janus ACSP纳米粒子 (NP) 合成了高Z元素 (Au) 以增强X射线吸收.
- 使用芬顿式反应来产生反应性氧物种 (ROS),影响细胞循环分布.
- 对NP对DNA损伤,修复途径和亡的影响在体外和体内都进行了研究.
主要成果:
- 纳米粒子通过芬顿式反应有效生成ROS,将细胞转移到放射敏感阶段.
- 在X射线辐射下,NP中的黄金 (Au) 增强了基的产生,增加了DNA损伤和亡.
- NP干扰了DNA损伤修复途径,延迟了修复并增强了放射敏感性.
结论:
- 开发的纳米粒子为化学动力学和放射敏感化疗法提供了一种协同方法.
- 将这种NP与低剂量X射线辐射相结合,有望提高放射治疗的有效性.
- 这项研究为基于纳米粒子的癌症治疗开发提供了有价值的策略.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K