住院患者患有非恶性外泄的急性损伤:一项回顾性队列研究
Danni Wang1, Yue Niu1, Dinghua Chen1
1Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing, 100853, China.
BMC nephrology
|April 1, 2024
概括
急性损伤 (AKI) 的发生率在非恶性流 (NMPE) 患者中很高. 适度和大排泄物显著增加AKI风险,排泄物大小对心力衰竭,肺炎和降低EGFR产生中介作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 非恶性流 (NMPE) 是一种常见的疾病,与急性损伤 (AKI) 有未知的关联.
- 了解NMPE患者中AKI的发病率以及液大小的作用对于患者管理至关重要.
研究的目的:
- 为了确定住院NMPE患者中AKI的发生率.
- 调查流体大小与发展AKI的风险之间的关联.
主要方法:
- 对3047名NMPE住院患者 (2018-2021) 的回顾性队列研究.
- 多变量和LASSO逻辑回归模型确定了AKI的风险因素.
- 因果调解分析评估了排泄量在通过心力衰竭,肺炎和低EGFR调解AKI中的作用.
主要成果:
- 11.8%的NMPE患者发生了AKI.
- 中度 (OR 1.47) 和大 (OR 1.86) 排泄物与小排泄物相比,独立地与增加的AKI风险有关.
- 输液量介于心力衰竭的6.8%,肺炎的4.0%,低EGFR对AKI发展的影响的4.6%.
结论:
- 在NMPE患者中,AKI的发病率特别高.
- 较大的肺溢体积独立地与较高的AKI风险有关.
- 胸腔溢液的大小在与心力衰竭,肺炎和功能下降相关的AKI的发展中起到调解作用.
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