生物活性层状双氧化物用于协同作用的声动力学/复性抗癌疗法,并诱导免疫反应
1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
ACS nano
|April 1, 2024
概括
这项研究引入了 Cu 替代的 ZnAl 层叠的双氧化物纳米片,用于组合声动力学疗法和cuproptosis. 这种方法有效地根除瘤并刺激抗瘤免疫力,解决传统声动疗法的局限性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 声动力疗法 (SDT) 对癌症治疗有希望,但与转移性瘤作斗争.
- 铜,一种依赖铜的细胞死亡途径,提供了一个新的治疗途径.
- 开发有效的纳米载体对于协同的癌症疗法至关重要.
研究的目的:
- 开发Cu-substituted ZnAl分层双氧化物纳米片 (ZCA NSs) 作为协同SDT和cuproptosis的双功能平台.
- 研究ZCA NSs在通过瘤微环境 (TME) 调制和优化电子结构来增强SDT的机制.
- 评估协同SDT/cuproptosis在根除原发性瘤和预防转移中的有效性,同时诱导抗瘤免疫力.
主要方法:
- 合成Cu替代的ZnAl三层层的双氧化物纳米片 (ZCA NSs).
- 对于电子结构和TME相互作用 (GSH耗尽) 的ZCA NSs的表征.
- 在体外和体内对协同SDT/cuproptosis疗效的评估,包括瘤根除,转移抑制和免疫反应诱导.
主要成果:
- 由于Cu2+的Jahn-Teller效应,ZCA NS具有针对SDT优化的电子结构.
- ZCA NSs有效地耗尽TME中的谷氨 (GSH),增强氧化应激和SDT.
- 协同的SDT/cuproptosis诱导免疫细胞死亡 (ICD),促进树突细胞 (DC) 成熟,消除体内瘤,并抑制肺/肝转移.
- 治疗引起了强大的抗瘤免疫力.
结论:
- ZCA NSs 作为一个有效的纳米平台,用于协同的声动疗法和cuproptosis.
- 这种联合疗法克服了SDT的局限性,消除了原发性瘤,并通过诱导抗瘤免疫力来预防转移.
- 开发的纳米平台为先进的癌症治疗提供了一个有前途的战略.
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