在vivo中,可代谢的原子精确au25集群在超高剂量的毒理学
Miaoyu Wang1, Fangzhen Tian2, Qi Xin2
1Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China.
Bioconjugate chemistry
|April 1, 2024
概括
超小金纳米集群 (AuNCs) 显示出出色的生物安全性,即使在超高剂量下也是如此. 研究表明没有显著的血液,组织或神经毒性,表明它们的生物医学应用潜力.
科学领域:
- 纳米医学是一种纳米医学.
- 生物材料是一种生物材料.
- 毒理学 毒理学 毒理学
背景情况:
- 超微小的金纳米集群 (AuNCs),特别是Au25(MPA) 18,具有有利于生物催化和生物成像的调节性质.
- 评估Au NCs的体内药理动力学和毒性对于其临床转化至关重要,特别是在高度下.
研究的目的:
- 调查AuNCs在超高剂量 (300和500毫克/公斤-1) 的体内血液学,组织和神经学影响.
- 评估AuNCs的生物安全概况,以对潜在的生物医学应用进行评估.
主要方法:
- 用300 mg和500 mgkg-1的AuNCs来评估体内效应.
- 生物化学和血液学参数的分析.
- 组织病理学检查和主要器官的免疫光染色.
- 实时近红外II (NIR-II) 成像以跟踪AuNC代谢.
主要成果:
- 生物化学和血液学参数保持在正常范围内,即使在500毫克/公斤-1剂量.
- 在主要器官中没有观察到他的病理学变化或明显的病变.
- NIR-II成像表明,Au25 ((MPA) 18) 和Au24Zn1 ((MPA) 18) 主要通过脏代谢.
结论:
- 在超高剂量时,AuNCs表现出有利的生物安全性,在主要器官中没有观察到显著的毒性作用.
- 脏是这些AuNCs的新陈代谢和分泌的主要途径.
- 这些发现提供了关键数据,支持AuNC在生物医学中的安全应用.
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