相关实验视频
Updated: Jun 29, 2025

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
18.8K
混合闭环自动胰岛素输送系统在1型糖尿病患者中的比较有效性
Sara Folk1, Janet Zappe2, Kathleen Wyne2
1The Ohio State University College of Medicine, Columbus, OH, USA.
Journal of diabetes science and technology
|April 1, 2024
概括
现实数据显示,混合闭环 (HCL) 系统可以改善1型糖尿病 (T1D) 的管理. 协同控制IQ (CIQ) 和Omnipod 5 (OP5) 显著降低了HbA1c,而Medtronic (MT) 系统在范围以下的时间更高.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病 技术 技术
- 临床研究 临床研究
背景情况:
- 混合闭环 (HCL) 系统在1型糖尿病 (T1D) 的临床试验中被证明是有效的.
- 不同HCL系统的现实世界比较结果数据仍然有限.
研究的目的:
- 为了比较三个主要的HCL系统的实际有效性:Medtronic 670G/770G (MT),Tandem Control IQ (CIQ) 和Omnipod 5 (OP5).
- 分析血糖控制指标,包括在范围内的时间 (TIR),范围以下的时间 (TBR) 和T1D患者开始HCL治疗的HbA1c.
主要方法:
- 对176名T1D患者 (年龄大于18岁) 的回顾性分析,这些患者在2018年至2022年期间开始HCL治疗.
- 在启动后90天 (TIR,TBR) 和91-180天 (HbA1c) 评估结果.
- 在MT,CIQ和OP5系统中对血糖控制的比较.
主要成果:
- 与基线相比,在CIQ和OP5观察到显著的HbA1c降低 (P=.04).
- 所有HCL系统的时间范围 (TIR) 都相似 (P=.95).
- 梅特罗尼克 (MT) 系统显示了较高的时间比范围 (TBR) 下的时间百分比 (P=.002).
结论:
- CIQ和OP5在现实环境中显示出HbA1c的显著改善.
- 虽然TIR是可比的,但TBR差异很大,在MT系统中最高.
- 自动交付时间的增加似乎影响了HbA1c的变化,但并没有影响HCL系统之间的TBR差异.
相关概念视频
Insulin: Dosing Regimen and Adverse Effects
169
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
169
Insulin Formulations: Types and Delivery
193
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
193
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Diabetes: Management and Pharmacotherapy
277
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
277
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K

