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Updated: Jun 29, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

在死性肠球炎中DNA甲基化.

Lauren C Frazer¹, Yukihiro Yamaguchi¹, Dhirendra K Singh¹

¹Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Expert reviews in molecular medicine

|April 1, 2024

概括

此摘要是机器生成的。

新生儿的DNA甲基化模式发生了改变,他们患有死性肠球炎 (NEC),这是一种严重的肠道疾病. 进一步的研究可能会确定这些表观遗传变化作为早期检测和向治疗的生物标志物.

关键词:

通过DNA甲基化.表观遗传学是指表观遗传学.肠道炎症肠道炎症死性肠球炎 (necrotizing enterocolitis) 是一种致死性肠球炎.新生儿新生儿新生儿新生儿时间过早的早产.

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Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

相关实验视频

Last Updated: Jun 29, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
新生儿健康新生儿健康
分子生物学分子生物学

背景情况:

表观遗传修饰,包括DNA甲基化,调节基因表达,对于早期发育和炎症反应至关重要.
虽然新生儿健康中的表观遗传学研究正在出现,但在早产疾病中的特定作用,如死性肠球炎 (NEC),正在调查中.
结核性肠球炎 (NEC) 是新生儿的一种严重的肠炎症疾病,其前因子和有效的生物标志物尚未完全确定.

研究的目的:

审查DNA甲基化在新生儿健康中的作用,重点关注其与死性肠球炎 (NEC) 的关联.
讨论最近关于NEC患者DNA甲基化模式的发现,并探索它们作为生物标志物的潜力.
提供DNA甲基化及其对疾病状态的影响的概述.

主要方法:

关于DNA甲基化和死性肠球炎 (NEC) 的最新科学文献的综述.
对报告新生儿NEC便和肠组织中DNA甲基化模式改变的研究进行分析.
探索DNA甲基化作为其他疾病背景中的生物标记物的实用性.

主要成果:

在被诊断患有NEC的新生儿的便和肠道组织中发现了改变的DNA甲基化模式.
这些发现表明表观遗传失调与NEC的发展之间存在潜在的联系.
目前的文献强调需要对这些甲基化模式进行进一步的研究.

结论:

改变的DNA甲基化模式是NEC研究的一个有希望的领域.
需要进一步的研究来验证DNA甲基化作为NEC的潜在生物标志物.
识别特定的甲基化模式可能会导致针对性疗法和NEC的改进诊断工具的开发.