年龄和大脑结构之间的关系在行为障碍的年轻人中是否不同?
Sarah Koerner1, Marlene Staginnus1, Harriet Cornwell1
1Department of Psychology, University of Bath, Bath, UK.
Research on child and adolescent psychopathology
|April 1, 2024
概括
年轻人的行为障碍 (CD) 与多个区域的大脑表面积的减少有关. 这项研究没有发现任何证据支持在研究年龄范围内的CD患者的大脑成熟延迟.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 行为障碍 (CD) 涉及持续的反社会和侵略性行为,通常在童年或青春期出现.
- 虽然被认为是一种神经发育障碍,但对CD中大脑发育的证据有限.
- 之前的研究表明,有结构性大脑变化,并有间接证据表明CD的成熟延迟.
研究的目的:
- 通过使用横截面MRI数据,研究患有CD的年轻人与健康对照人之间大脑成熟的差异.
- 了解行为障碍背后的神经发育过程.
- 分析患有CD的青少年大脑结构与年龄相关的变化.
主要方法:
- 利用来自FemNAT-CD研究的291例CD病例和379名健康对照 (年龄9-18岁) 的横截面MRI数据.
- 采用基于表面的形态测量和ENIGMA质量控制协议进行结构性MRI分析.
- 使用基于图谱的方法来检查皮质厚度,表面积和皮质下体积的群体差异和按年龄/性别的群体相互作用.
主要成果:
- 与对照组相比,CD组在额头部,部和部区域的表面积明显较小.
- 行为障碍患者的总表面积也减少了.
- 对于任何大脑结构指标,没有发现显著的按年龄组或按年龄组和按性别组的相互作用.
结论:
- 行为障碍与年轻人的多个大脑区域的皮质表面积减少有关.
- 这些发现不支持在9-18岁年龄范围内的CD中大脑成熟延迟的假设.
- 需要进一步的研究,以充分阐明行为障碍的神经发育方面的问题.
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