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Updated: Jun 29, 2025

Imaging the Human Immunological Synapse
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Imaging the Human Immunological Synapse

Published on: December 26, 2019

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在同步生活:基于突触测序的T细胞抗原识别.

Venkata Krishna Kanth Makani1,2,3, Alok V Joglekar1,2,3

  • 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Cancer immunology research
|April 1, 2024
PubMed
概括

研究人员开发了Tsyn-seq,这是一个用于发现T细胞表位的新平台. 这种方法对T细胞受体--人白细胞抗原相互作用的序列进行基因组范围内的已知表位体查.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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