血清二碳酸盐水平和重症患者的结局:一个前性队列研究
Heitor S Ribeiro1,2,3, Marvery P Duarte1, Emmanuel A Burdmann3
1Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
International urology and nephrology
|April 1, 2024
概括
在重症监护室 (ICU) 患者的低血清二碳酸盐水平增加了急性损伤 (AKI) 和功能恢复受损的风险. 高水平的二碳酸盐并没有显示出类似的关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 关键护理医学 关键护理医学
- 内部医学 内部医学
背景情况:
- 血清二碳酸盐与重症患者结局之间的关系尚不清楚.
- 本研究调查了血清二碳酸盐水平与急性损伤 (AKI) 和重症监护室 (ICU) 患者的功能恢复之间的关联.
研究的目的:
- 评估血清二碳酸盐水平与AKI发展的关联.
- 评估血清二碳酸盐对重症患者功能恢复的影响.
- 为了确定血清二碳酸盐水平是否与ICU患者的死亡率有关.
主要方法:
- 在三个ICU中进行了前性队列研究.
- 血清二碳酸盐水平被分为低 (<22 mEq/L),正常 (22-26 mEq/L) 或高 (>26 mEq/L) 在ICU入院后24小时内.
- 根据KDIGO指南,根据在ICU停留7天内的血清肌水平来定义急性损伤 (AKI).
主要成果:
- 与正常水平相比,低血清二碳酸盐水平与患AKI的可能性增加81%有关.
- 高血清二碳酸盐水平与发展AKI的可能性下降44%有关.
- 低碳酸盐水平与更高的功能在医院出院后无法恢复的比例相关.
结论:
- 低血清二碳酸盐水平是危重病重症病房患者不良脏结果的潜在危险因素.
- 血清二碳酸盐水平与AKI发展和功能恢复有关.
- 血清二碳酸盐水平和28天死亡率之间没有发现显著的关联.
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