在肥胖儿童中观察到的异常骨周转率基于青春期阶段特定的骨周转率标志物参考值
Chushan Wu1, Zhuoguang Li1, Yanyan Li2
1Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen 518026, China.
The Journal of clinical endocrinology and metabolism
|April 1, 2024
概括
这项研究为儿童和青少年建立了关键的年龄,性别和青春期特定的骨周转标记参考曲线. 肥胖对男孩的骨形成和女孩的骨再吸收有负面影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨代谢研究研究 骨代谢研究
- 青少年健康 青少年健康
背景情况:
- 童年和青春期对于终身骨健康至关重要.
- 在这些时期肥胖对骨健康的影响仍在争论中.
- 缺乏标准化的,特定于年龄,性别和青春期的骨转化标志物 (BTM) 阻碍了对骨代谢的准确评估.
研究的目的:
- 为儿童和青少年的BTM开发特定于年龄,性别和青春期阶段的参考曲线.
- 研究肥胖对中国儿科人口骨代谢的影响.
主要方法:
- 利用了深学校营养与成长研究的数据.
- 使用800名正常BMI参与者 (6-18岁) 建立BTM参考曲线.
- 对比了200名肥胖参与者 (BMI>95百分位) 和匹配的健康对照,测量骨矿物质密度,P1NP类型的N-propeptide (P1NP) 和I型原蛋白的β-C-telopeptide (CTX).
主要成果:
- 根据年龄,性别和青春期的阶段,BTM显示出显著的差异.
- 肥胖男孩表现出较低P1NP水平 (表明骨形成减少) 的更高流行率.
- 肥胖女孩在CTX水平上升的比例更高 (表明骨再吸收增加).
结论:
- 为P1NP和CTX生成年龄,性别和青春期阶段特定的参考曲线.
- 肥胖对男孩的骨形成和女孩的骨再吸收有负面影响.
- 这些发现为评估儿童群体与肥胖有关的骨健康提供了必要的基准.
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