辛吉伯树的保护作用 Zerumbet根茎对大鼠发烧的保护作用
Haslinda Mohd Salleh1, Abdulwali Ablat1, Soon-Lim Chong1
1Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Die Naturwissenschaften
|April 1, 2024
概括
来自Zingiber zerumbet根茎 (EAEZZR) 的乙烯酸提取物在5000毫克/公斤以下是安全的,并且在老鼠中表现出显著的抗发烧活性. 这表明,有可能治疗与登革热病毒感染相关的发烧.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 民族植物学 民族植物学
- 自然产品化学 自然产品化学
背景情况:
- 树的根茎具有治疗发烧的传统医疗用途.
- 之前的研究表明,EAEZZR.在体外抑制了登革热病毒2型 (DENV2) 非结构蛋白.
- 在体内,EAEZZR的确定的抗热作用尚未得到充分的描述.
研究的目的:
- 为了确定EAEZZR在Sprague Dawley大鼠中的急性毒性概况.
- 用酵母诱导的发烧模型评估EAEZZR的抗热 (抗发烧) 疗效.
- 从EAEZZR.中分离并从结构上阐明主要活性化合物泽伦.
主要方法:
- 根据经合组织试验指南425在2000,3000和5000毫克/公斤的剂量中评估了急性毒性.
- 在患有酵母引起的炎症的老鼠中评估了抗炎活性,测量了直肠温度 (TR) 的变化.
- 基隔离使用柱状染色学和准备性薄层染色学;结构确认涉及NMR,LCMS-IT-TOF,IR和UV光谱学.
主要成果:
- 在最高测试剂量5000 mg/kg时,EAEZZR证明了安全性.
- 在EAEZZR剂量为125,250和500毫克/公斤时,在1小时内观察到直肠温度的显著降低.
- 服用125mg/kg的EAEZZR可持续降低高达2小时的发烧,而阿司匹林可在3至4小时内起效.
结论:
- 树根茎的乙烯酸提取物是安全的消费量高达5000毫克/公斤体重.
- 在动物模型中,EAEZZR表现出显著且剂量依赖的抗炎性质.
- 研究结果支持Zingiber zerumbet用于发烧的传统用途,并建议潜在的治疗应用,特别是在登革热病毒感染中.
相关概念视频
01:22Methods of reducing fever
662
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
662
01:25Increased Body Temperature
667
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
667
01:29Decreased Body Temperature
615
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
615