乳腺肥胖:更年期状态影响及其对血糖和人类代谢参数的影响
Barbara Limberger Nedel1, Michelle Garcia Madure2, Silvia Guaresi3
1Graduate Program in Medical Sciences: Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 90035-000, Brazil.
The Journal of clinical endocrinology and metabolism
|April 1, 2024
概括
乳腺脂肪组织 (BrAT) 积累与绝经后妇女的代谢问题有关. 这项研究发现,乳腺脂肪增加与高血糖和代谢综合征相关,突出显示了更年期期间潜在的内分泌作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 妇女健康 妇女健康
背景情况:
- 宫外脂肪储存导致能量失衡,肥胖和代谢综合征 (MetS).
- 乳腺脂肪组织 (BrAT) 在不同绝经阶段的妇女中作为宫外脂肪储存的作用尚未得到充分研究.
- 身体成分在妇女的整个生命周期中发生显著变化,特别是在更年期左右.
研究的目的:
- 研究成年女性的BrAT和代谢 (血糖和脂质) 概况之间的关联.
- 探索BrAT和身体组成参数之间的关系.
- 确定更年期状态是否影响这些关联.
主要方法:
- 涉及成年女性接受乳房扫描的横截面研究.
- 评估身体组成,乳腺脂肪 (BA) 从乳房影像,和生化参数从禁食血液样本.
- 使用相关性和多变量回归的统计分析来检查BA和代谢/身体组成因素之间的关联.
主要成果:
- 在绝经后的女性中,增加乳腺脂肪 (BA) 与更高的禁食血葡萄糖,糖化血红蛋白,胰岛素耐药性 (HOMA-IR),BMI,腰围,身体脂肪百分比和腹部内脏/皮下脂肪相关.
- 乳腺脂肪 (BA) 在绝经后妇女中独立预测高血糖和代谢综合征 (MetS).
- 在绝经前妇女中没有观察到这些关联.
结论:
- 乳腺脂肪 (BA) 与绝经后妇女的不良身体组成和代谢因素有关.
- 这些发现表明,在更年期期间Brat的潜在内分泌功能,保证进一步的研究.
- 这项研究为研究BrAT在代谢健康中的作用和潜在的临床影响开辟了道路.
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