控制不良的儿科1型糖尿病是代谢功能障碍相关脂肪性肝病 (MASLD) 的危险因素:一项观察性研究:
Florian Koutny1,2, Dagobert Wiemann3, Alexander Eckert4
1Department of Human Medicine, PhD Medical Science, Paracelsus Medical University, Salzburg, Austria.
Journal of pediatric gastroenterology and nutrition
|April 1, 2024
概括
在儿童中控制不良的1型糖尿病 (T1D) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关,即使没有超重. 有效的糖尿病管理对于预防儿科患者的MASLD至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 新出现的证据表明,儿童群体的1型糖尿病 (T1D) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间存在联系.
- 在儿童和青少年中澄清这种关联的纵向数据仍然有限.
研究的目的:
- 研究儿童和青少年不充分控制的T1D和MASLD标志物氨氨酸转移酶 (ALT) 水平升高之间的纵向关联.
- 评估T1D控制和MASLD风险与时间的关系.
主要方法:
- 分析了来自德国,奥地利和瑞士的32325名患有T1D的儿童 (年龄为2-17岁).
- 肝酶水平的评估是使用来自糖尿病患者流程记录的数据进行的.
- 多变量后勤和考克斯回归模型被用来评估T1D控制和ALT升高 (>26U/L在男性,>22U/L在女性) 之间的关联.
主要成果:
- 患T1D控制不良的儿童 (HbA1c>11%) 显著增加了ALT升高的几率 (OR2.54;p<0.01),而不依赖于超重.
- 纵向分析显示,不充分控制的T1D与随时间升高的ALT风险相关 (HR 1.54;p<0.01).
结论:
- 在儿童和青少年中控制不良的T1D与MASLD密切相关,无论超重状态如何.
- 这种关联在横截面上显而易见,在纵向上增加,突出显示了血糖控制的重要性.
- 有效的糖尿病管理对于减轻这种脆弱人群中发展MASLD的风险至关重要.
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