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在胎儿有皮层发育形的胎儿中,体的不成比例

Yu-Ting Jiang¹, Xiao-Jing Zeng¹, Miao He¹

¹Department of Ultrasonic Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

|April 1, 2024

概括

胎儿体 (CC) 尺寸在皮质发育形 (MCD) 中减少. 脑脊长度与内脑前角尺寸 (CCL/ICOFD) 的比率显示出这些大脑异常的产前检测具有前途.

科学领域:

产前诊断和胎儿医学.
神经成像和发育生物学.

背景情况:

皮层发育形 (MCD) 是一组先天性脑部异常.
准确的MCD产前诊断对于适当的管理和咨询至关重要.
体 (CC) 异常经常与MCD相关.

研究的目的:

在被诊断为皮质发育形 (MCD) 的胎儿中评估体 (CC) 大小.
评估三个CC长度 (CCL) 比率在识别胎儿皮层异常时的诊断效用.

主要方法:

在2017年4月至2022年8月期间对单个胎儿 (妊娠20-37周) 的回顾性分析.
分析了中关节胎儿大脑图像的CC长度,高度和面积.
评估的CC长度比:CCL/内部头骨前角尺寸 (ICOFD),CCL/大腿长度 (FL) 和CCL/大脑毛虫直径 (VD).
使用接收器运行特征 (ROC) 曲线和曲线下的面积 (AUC) 来确定诊断准确度.

主要成果:

与对照组相比,患有MCD的胎儿显著减少了CC长度,高度 (膝盖和) 和面积 (P < .05).
在患有MCD的胎儿中,所有三种CC长度比率 (CCL/ICOFD,CCL/FL,CCL/VD) 都显著下降 (P < .05).
CCL/ICOFD比率显示MCD的预测准确度最高 (AUC = 0.856),其次是CCL/FL (AUC = 0.780) 和CCL/VD (AUC = 0.677).

结论:

在患有MCD的胎儿中,体的生物识别参数显著减少.
由超声波测量得出的CCL/ICOFD比率是用于产前检测皮质形的一个有希望的工具.
建议进行进一步的外部验证和前性研究来证实这些发现.

关键词:

身体的质体 (callosum) 是一个体.皮层发育的形.迁移障碍迁移障碍迁移障碍神经声谱 (neurosonography) 是一种神经声谱.产前诊断在产前诊断.

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