在儿科克罗恩病中逆向工程专用肠道营养:试点试验
Dale Lee1, Kim Braly1, Mason Nuding1
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Inflammatory Bowel Disease Center, Seattle Children's Hospital, Seattle, Washington, USA.
Journal of pediatric gastroenterology and nutrition
|April 1, 2024
概括
一种全食 Smoothie 在儿科克罗恩病 (CD) 患者中有效诱导缓解,类似于商业配方. 这种饮食方法也对CD儿童的肠道微生物组合产生了积极的影响.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 微生物组研究 微生物组研究
背景情况:
- 使用商业配方的独家肠道营养 (EEN) 是对儿科克罗恩病 (CD) 缓解的经过验证的治疗方法.
- 基于全食物的EEN在儿科CD中的有效性需要进一步研究.
研究的目的:
- 评价一个全食混合的冰沙作为EEN诱导儿童CD的缓解.
- 评估整个食品EEN对疾病活动和肠道微生物群的影响.
主要方法:
- 一项为期4周的前性试验,涉及新诊断的轻度至中度活跃儿科CD患者.
- 参与者获得了营养完整的全食 Smoothie 和多维生素.
- 使用儿科克罗恩病活动指数 (PCDAI),便calprotectin (FCP) 和血清实验室测量疾病活性. 微生物组分析使用了元基因组猎枪测序.
主要成果:
- 80%的参与者在第4周内实现了临床缓解 (PCDAI ≤10).
- 便中calprotectin (FCP) 水平显著下降,超过一半的便中calprotectin (FCP) 水平降低了50%以上.
- 微生物组分析显示,物种丰富度增加,细菌数量发生显著变化,包括Bifidobacterium和Streptococcus的增加.
结论:
- 一种全食混合的冰沙EEN在诱导临床缓解和减少儿科CD中的FCP方面是有效的.
- 这种方法显示了与商业EEN配方相比的效果.
- 结果支持进一步研究全食饮食策略,用于管理儿科CD.
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