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骨髓移植和骨髓衍生的骨髓干细胞治疗在表皮质溶解:一个系统的审查
Maulidina Agustin1, Anita Mahadewi2, Retno Danarti1
1Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Pediatric dermatology
|April 1, 2024
概括
骨髓移植 (BMT) 和骨髓衍生的介质干细胞 (BM-MSCs) 显示出治疗严重表皮质溶解牛 (EB) 的前景. 虽然BMT带有风险,但BM-MSC可以改善伤口愈合,并减少EB患者的不良事件.
科学领域:
- 皮肤病学 皮肤病学
- 再生医学是一种再生医学.
- 血液学 血液学 血液学
背景情况:
- 牛皮表皮溶解 (EB) 是一种严重的遗传性皮肤疾病,缺乏有效的治疗方法,需要支持性护理.
- 骨髓移植 (BMT) 和其衍生细胞正在探索改善EB症状和生活质量.
研究的目的:
- 为了评估BMT和骨髓衍生中介细胞干细胞 (BM-MSC) 治疗表皮溶解牛皮的疗效和安全性.
- 分析EB患者用这些基于细胞的疗法治疗的临床结果和不良事件.
主要方法:
- 在PubMed/MEDLINE,Google Scholar和Cochrane数据库中进行了全面的文献搜索,直到2023年6月.
- 分析了55名患有严重EB的参与者接受了BMT和/或BM-MSC治疗的数据.
主要成果:
- 受试者中最常见的类型是衰退性衰变性EB.
- 超过96%的患者经历了改善的伤口愈合,而5.5%的患者死于败血症.
- 常见的不良事件包括移植失败,败血症,移植与宿主疾病和功能不全.
结论:
- 全基性BMT是一种EB的高风险手术,具有潜在的益处和显著的不良事件.
- BM-MSCs表现出良好的结果,通过减少不良事件,水泡和加速伤口愈合来提高安全性.
- 需要进一步的研究来确定基于细胞的疗法与传统EB治疗的长期影响和风险/益处比率.
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