在现实生活中,超声波对类风湿性关节炎 (RA) 活动评估的全球OMERACT-EULAR膜炎评分 (GLOESS) 如何表现?
Nicole Pamplona Bueno de Andrade1,2, Claiton Viegas Brenol2, Rafael Mendonça da Silva Chakr1,2
1Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
概括
全球OMERACT-EULAR协炎评分 (GLOESS) 测量甲骨关节 (MCP 2-5) 在现实环境中有效测量类风湿性关节炎 (RA) 活动. 一个GLOESS分数为3或以下表明疾病活性较低.
科学领域:
- 类风湿病学 类风湿病学
- 肌肉骨超声波 肌肉骨超声波
- 疾病活动评估 疾病活动评估
背景情况:
- 类风湿性关节炎 (RA) 需要精确监测疾病活动.
- 肌肉骨超声波 (MSUS) 提供了对膜炎的客观测量.
- 对于真实世界RA评估,需要标准化的评分系统.
研究的目的:
- 在评估RA活动时,评估全球OMERACT-EULAR协炎评分 (GLOESS) 对于甲手关节 (MCP 2-5) 的评价.
- 为了确定GLOESS在临床环境中的有效性.
- 建立GLOESS的切割值,以区分疾病活动水平.
主要方法:
- 在没有过敏症的RA患者的横截面研究.
- 从电子医疗记录中提取的临床数据.
- 双边MCP 2-5 联合由两个MSUS专家进行评估.
- 在GLOESS和临床参数之间的相关性分析 (DAS28-ESR).
主要成果:
- 其中包括69名RA患者.
- 在GLOESS和DAS28-ESR之间发现了中等相关性 (r=0.62,P<0.05).
- 截止值≤3的GLOESS显示出检测疾病活动的良好的灵敏度和特异性 (缓解/低与中度/高).
结论:
- MCP 2-5 的 GLOESS 是在现实临床实践中评估 RA 活性的一个有价值的工具.
- 一个最佳的GLOESS ≤3的切线有效地区分了缓解/低和中度/高的RA疾病活动.
- 这一分数有助于客观的RA管理和治疗决策.
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