探索优化益生菌补充技术对糖尿病病的影响:机制和治疗潜力
Anindita Ghosh1,2, Arti Muley1, Archana S Ainapure2
1Nutrition and Dietetics, Symbiosis Institute of Health Sciences, Symbiosis International (Deemed University), Pune, IND.
Cureus
|April 1, 2024
概括
益生菌补充剂通过改善功能和代谢标志物,在治疗糖尿病病 (DN) 中表现有前途. 需要进一步的研究来优化益生菌的使用,以减缓DN进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 微生物学 微生物学
- 营养 营养 营养 营养 营养
背景情况:
- 糖尿病病 (DN) 是全世界末期病的主要原因之一.
- 益生菌补充正在作为一种营养疗法来改善各种健康标志物的探索中.
- 益生菌对DN的有效性和最佳使用需要彻底调查.
研究的目的:
- 审查有关糖尿病病益生菌补充剂的当前文献.
- 评估益生菌对DN患者功能,血糖控制和其他生物标志物的影响.
- 为了确定最佳的益生菌剂量,持续时间和组合来管理DN.
主要方法:
- 2013-2023年随机对照试验,系统审查和元分析的文献综述.
- 在MEDLINE (PubMed),Scopus和Web of Science上使用关键词进行了搜索:肠道微生物群,肠道微生物组,糖尿病病,糖尿病病,益生菌和益生菌.
- 分析的重点是研究报告脏,葡萄糖和脂质生物标志物的变化后益生菌的管理.
主要成果:
- 益生菌补充剂,特别是像*Bifidobacterium bifidum*,*Lactobacillus acidophilus*和*Streptococcus thermophilus*这样的菌株,显示了糖化血红蛋白,禁食血糖和微型白血病/肌素比率的降低.
- 多种类和单种类的益生菌 (含有 * Lactobacillus,Bifidobacterium,Streptococcus thermophilus spp. * > 4x10^9 CFU/天8-12周) 改善了DN患者的代谢标志物和疾病进展.
- 综合益生菌,益生菌和协生菌补充剂对血糖控制,功能,脂质谱,炎症和氧化应激有积极影响.
结论:
- 益生菌补充剂对糖尿病病患者有潜在的益处.
- 特定的益生菌菌株,剂量和持续时间在改善关键健康标志物方面表现有前途.
- 未来的大规模,长期随机对照试验是必要的,以确认发现,并建立最佳的治疗策略,包括益生菌,益生菌和共生菌DN.
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