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是由Corynespora cassiicola引起的,它是全世界的一种植物病原体
Dongying Hu1, Weiwei Jiang1, Xinlin Zhu1
1Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Mycology
|April 1, 2024
概括
跨王国真菌感染,如由Corinespora cassiicola引起的真菌感染,很少见,但可以影响人类. 本文重点介绍了形形菌病的关键方面,强调了分子诊断和有效的治疗方法.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 病原体生物学 病原体生物学
背景情况:
- 跨王国感染涉及病原体跨越物种障碍,造成诊断和治疗挑战.
- 一种植物病原体Corynespora cassiicola,偶尔会导致人类的菌菌,一种罕见的真菌感染.
- 零星病例报告需要全面审查,以提高认识和管理.
研究的目的:
- 系统地审查和分析报告的由Corynespora cassiicola引起的形形菌病例.
- 阐明传播途径,临床表现,诊断方法和治疗结果.
- 为改善这种罕见的真菌感染的临床管理提供见解.
主要方法:
- 系统的文献审查已发表的Corynespora cassiicola感染病例.
- 来自确定的患者的临床数据的聚合分析.
- 对诊断技术的审查,包括生化,形态和分子方法 (ITS测序).
- 对治疗方案和患者结果的分析.
主要成果:
- 其中包括9起病例,其中大多数是在2010年之后报告的,来自亚洲,非洲和拉丁美洲的农业地区.
- 暴露的身体部位通常受到影响,呈现出非特异性炎症反应.
- 在大多数情况下,分子识别,特别是内部转录间隔序列,对于诊断至关重要.
- 虽然几种抗真菌药物显示出成功,但侵入性面部感染和CARD9缺乏症与糟糕的结果有关.
- 伊特拉可纳治疗被发现是无效的.
结论:
- 分子鉴定和及时的抗真菌治疗对于成功管理形菌症至关重要.
- 科里尼斯波拉 (Corynespora cassiicola) 是一种罕见但严重的威胁,特别是在农业社区.
- 应量身定制治疗策略,避免伊特拉科纳,并考虑患者特定的因素,如侵入性疾病或免疫缺陷.
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