对低度尾粘膜瘤 (LAMN) 的积极监测
Christian Mouawad1,2, Armelle Bardier3, Mathilde Wagner4
1Department of Digestive, Hepatobiliary and Liver Transplantation Surgery, AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Pleura and peritoneum
|April 1, 2024
概括
积极监测 (AS) 是偶然发现的低度尾粘膜瘤 (LAMN) 的可行管理策略. 这种利用MRI的方法表明,在患有低伪肌瘤进展风险的患者中,疾病稳定率很高.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 低度尾粘膜瘤 (LAMN) 缺乏标准化的管理指南,特别是在偶然发现的病例中.
- 假瘤周周的进展风险需要谨慎的监测策略.
研究的目的:
- 评估积极监测 (AS) 策略对偶然诊断的LAMN.的有效性.
- 评估MRI在预测LAMN患者疾病进展中的作用.
主要方法:
- 附带诊断为LAMN且 Pseudomyxoma进展风险较低的30名患者被纳入.
- 积极监测包括体检,瘤标志物和腹腔皮层MRI,最初每6个月一次,然后每年进行10年.
- 纳入标准需要LAMN确认,有限的尾外粘素,正常的瘤标志物和正常的基线MRI.
主要成果:
- 87%的患者在平均3.1年的随访期间在MRI上没有表现出疾病进展.
- 在13%的患者中,病情进展到形瘤 (PMP).
- 在手术后的第一年,MRI在97%的病例中准确预测了预后.
结论:
- 以MRI为指导的积极监测是偶然LAMN的安全和有效的管理选择.
- 早期的MRI发现对LAMN患者的长期疾病结果具有很高的预测性.
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