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使用CellCap建模细胞状态和扰乱反应之间的可解释对应

Yang Xu1, Stephen Fleming1, Matthew Tegtmeyer2,3

  • 1Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA.

bioRxiv : the preprint server for biology
|April 1, 2024
PubMed
概括

一个新的深度生成模型CellCap分析单细胞扰动数据,以揭示细胞状态特定的反应. 它捕捉了异构的细胞行为,提供了对分子机制和潜在治疗点的见解.

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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...