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The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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八角座:基于磁盘的,多平台的,移动友好的元基因组学分类器.

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概括
此摘要是机器生成的。

随身携带的基因组测序分析现在可以在智能手机上使用OCTOPUS软件. 该工具提高了纳米孔数据的元基因组分类准确性,减少了现场应用中的错误阳性.

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科学领域:

  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.
  • 计算生物学 计算生物学

背景情况:

  • 像牛津纳米孔的MinION这样的便携式基因组测序器在临床和环境健康方面提供实时应用.
  • 对基因组数据的下游生物信息学分析面临瓶,特别是当云处理不可用或只有低端设备可访问时.

研究的目的:

  • 开发一个平台友好的软件,用于纳米孔测序数据的便携式元基因组分析.
  • 在资源有限或离线环境中解决现有的生物信息管道的局限性.

主要方法:

  • 开发了基于Java的软件OCTOPUS (基于Oligomer的分类学操作和泛基因组单元通过单元),一个基于Java的软件.
  • 重新实现了Kraken2和KrakenUniq的功能,结合了用于在不完整的参考数据库上改进分类的新型组件.
  • 优化了软件以在智能手机和平板电脑等移动设备上执行.

主要成果:

  • 对于元基因组分类,OCTOPUS的灵敏度和精度与Kraken2相美.
  • 与现有工具相比,证明了虚假阳性率的显著降低,从4倍到16倍.
  • 在真实数据上验证的性能,显示与预期结果的高相关性.

结论:

  • 奥克托普斯为纳米孔数据的便携式元基因组分析提供了一种高效和准确的解决方案.
  • 该软件适合在移动设备上部署,克服了连接和计算能力的限制.
  • 奥克托普斯增强了便携式测序在现场临床和环境健康应用中的实用性.