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Updated: Jun 29, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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通过非催化域调节APOBEC3GDNA编辑功能的分子机制

Hanjing Yang1, Josue Pacheco1, Kyumin Kim1

  • 1Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

bioRxiv : the preprint server for biology
|April 1, 2024
PubMed
概括

APOBEC3G (A3G) 使用其非催化域捕获DNA图案,增强其抗病毒编辑. 这种A3G域之间的相互作用对于免疫防御和理解癌症突变至关重要.

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