Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

JCO oncology practice·2026
Same author

Topological Data Analysis of Spatial Protein Expression in Multiplexed Spatial Proteomics Studies.

bioRxiv : the preprint server for biology·2026
Same author

Whole-protein screening and multi-modal profiling of antigen-specific CD4<sup>+</sup> T cells at single-cell resolution.

Nature communications·2026
Same author

MONETTE: A Randomized Phase II Study of Ceralasertib plus Durvalumab or Ceralasertib Monotherapy in Patients with Advanced Melanoma Resistant to PD-(L)1 Inhibition.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Cellular neighborhoods govern antitumor T-cell infiltration following anti-CTLA-4 in melanoma with primary resistance to anti-PD-1.

Cancer discovery·2026
Same author

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.

Nature communications·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 29, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K

一个空间总体测试 (SPOT) 空间蛋白质数据的空间总体测试.

Sarah Samorodnitsky1,2, Katie Campbell3, Antoni Ribas3

  • 1Public Health Sciences Division, Fred Hutch Cancer Center.

bioRxiv : the preprint server for biology
|April 1, 2024
PubMed
概括
此摘要是机器生成的。

一种新的方法,空间总体测试 (SPOT),分析了免疫细胞在多个半径的瘤中的空间聚类. 这种方法增强了将空间组织与患者结果联系起来的能力,提供了有价值的临床见解.

更多相关视频

SpOT the Correct Tissue Every Time in Multi-tissue Blocks
06:53

SpOT the Correct Tissue Every Time in Multi-tissue Blocks

Published on: May 31, 2015

11.8K
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

557

相关实验视频

Last Updated: Jun 29, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
SpOT the Correct Tissue Every Time in Multi-tissue Blocks
06:53

SpOT the Correct Tissue Every Time in Multi-tissue Blocks

Published on: May 31, 2015

11.8K
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

557

科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 生物统计学 生物统计学

背景情况:

  • 空间蛋白质组学对于理解瘤免疫微环境至关重要.
  • 现有的空间聚类措施 (例如,里普利的K) 需要预定义的半径,缺乏对最佳选择的共识.
  • 这种局限性阻碍了对空间组织和患者结果的强有力的分析.

研究的目的:

  • 引入空间综合测试 (SPOT),一种用于分析免疫细胞空间聚类的新型统计方法.
  • 克服空间分析中预先指定半径的局限性.
  • 提供一个强大的工具,将空间免疫细胞组织与临床结果联系起来.

主要方法:

  • SPOT分析了一系列半径的空间聚类.
  • 它评估了空间总结和结果之间的关联,在每个半径上调整了混因素.
  • 结果使用考奇组合测试进行汇总,以产生全方位的p值.

主要成果:

  • 模拟证实了SPOT控制的I型错误率.
  • 与替代方法相比,SPOT显示了更好的统计能力.
  • 该方法已成功应用于卵巢癌研究.

结论:

  • SPOT提供了一种全面的方法来评估瘤微环境中的空间免疫细胞组织.
  • 该方法提供了一个强大的框架,用于识别空间模式和患者结果之间的关联.
  • 一个R包和教程可用于更广泛的应用.