在对手的认知-动机风格中固有的皮层-状动作控制
Cassandra Avila1, Martin Sarter1,2
1Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
bioRxiv : the preprint server for biology
|April 1, 2024
概括
皮层-状突起控制了指针转向行为,指向目标的老鼠比指针驱动的老鼠表现出更强的控制能力. 这突显了注意力运动系统的个体差异和神经系统疾病的潜在脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 认知神经科学 认知神经科学
背景情况:
- 适应性行为依赖于整合注意力和运动控制.
- 在将感官线索与行为行为联系起来时,皮层-状突出的投影至关重要.
- 了解这种接口是解释神经和精神疾病缺陷的关键.
研究的目的:
- 调查皮层-状突起在诱导作用选择和抑制中的作用.
- 检查认知-激励风格 (目标导向与提示驱动的注意力) 如何影响皮质-状控制.
- 阐明在背中状体中引起的谷氨酸释放的神经机制.
主要方法:
- 使用谷氨酸感应微电极阵列测量鼠标背中条体中的谷氨酸过渡物在指令任务期间.
- 采用化学遗传学来抑制前临床皮质到背中状体投射.
- 基于注意偏差,区分目标追踪器 (GT) 和标志追踪器 (ST).
主要成果:
- 皮层-状突起显著影响了cued转,但没有cued停止.
- 目标导向的老鼠 (GTs) 与标志驱动的老鼠 (STs) 相比,表现出更强的皮质-状控制.
- 谷氨酸释放模式在GT和ST之间有所不同,这表明了不同的调节机制.
结论:
- 皮层 - 皮层路径对于选择指导行动,特别是转,至关重要.
- 注意力策略的个体差异会影响皮层-层功能.
- 研究结果提供了关于运动控制缺陷的神经基础和潜在治疗点的见解.
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