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相关概念视频

Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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相关实验视频

Updated: May 2, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

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I型干扰素改变了侵入性外性热囊细胞的功能.

Michael K Simoni, Seble G Negatu, Ju Young Park

    bioRxiv : the preprint server for biology
    |April 1, 2024
    PubMed
    概括

    过度的I型干扰素 (IFN) 信号破坏了胚胎植入,阻碍了 trofhoblast 细胞的入侵和血管重塑. 这种干扰与孕前有关,这是一个严重的妊娠并发症.

    科学领域:

    • 生殖生物学 生殖生物学
    • 免疫学 免疫学 免疫学
    • 发育生物学是发展生物学.

    背景情况:

    • 不适当的I型干扰素 (IFN) 信号传输与不良妊娠结果有关.
    • 了解IFN在胚胎植入和胎盘中的作用对于母亲健康至关重要.

    结论:

    • I型IFN信号破坏了EVT上皮细胞到介质细胞的过渡,影响了螺旋动脉的重塑.
    • 由IFN诱导的异常EVT功能可能有助于孕前的发展.
    • 这项研究涉及I型IFN作为潜在的孕前引发的孕产妇因素.

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