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Updated: May 13, 2026

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus
09:43

Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus

Published on: April 24, 2014

仙台病毒的持久性质疑了iPSC生成的短暂的天真重编程方法.

Alejandro De Los Angeles1, Clemens B Hug2, Vadim N Gladyshev3

  • 1McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge MA, USA.

bioRxiv : the preprint server for biology
|April 1, 2024
PubMed
概括

暂时的天真治疗 (TNT) 可能会改善诱导多能干细胞 (iPSC),但持续的仙台病毒表达可以改变重编程因素. 对于转基因独立的iPSC生成,需要进一步的研究.

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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

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Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.