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Updated: Jun 29, 2025

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正对的IMiD-Degron对诱导细胞中的选择性蛋白质降解

Patrick J Brennan1,2, Rebecca E Saunders3, Mary Spanou4

  • 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford; Oxford, UK.

bioRxiv : the preprint server for biology
|April 1, 2024
PubMed
概括

研究人员开发了一种选择性蛋白质降解系统,使用改性免疫调节性胺基药物 (IMiD) 和指 (ZF) 突变物. 这种方法精确地针对蛋白质进行降解,避免细胞组件如IKZF1和IKZF3.3的意外降解.

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