21世纪的自然产品合成:超越山顶
1Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
ACS central science
|April 1, 2024
概括
自然产品的合成,植根于古代的物质医学,已经与有机化学进化. 化学生物学和数据科学等现代工具正在为未来的进步重新振兴这个领域.
科学领域:
- 有机化学 有机化学
- 化学生物学 化学生物学
- 自然产品的合成自然产品的合成
背景情况:
- 来自植物和真菌的天然产品历来提供了像吗啡和psilocybin这样的关键化合物.
- 自然产品合成是为了克服供应限制和探索新的分子特性而出现的.
- 该领域的重点转向反应发展和催化,大约20年前,复杂分子合成在美国的下降.
研究的目的:
- 为广泛的受众将自然产品合成的历史和当前景观置于背景中.
- 探索自然产品合成的未来转型.
- 突出合成,化学生物学和数据科学之间的协同作用.
主要方法:
- 自然产品研究及其演变的历史分析.
- 讨论向反应开发和应用驱动型研究的转变.
- 探索结合化学生物学和数据科学的新兴趋势.
主要成果:
- 自然产品合成为有机化学提供了基本的见解.
- 该领域最近的收缩是由专注于反应发展而不是复杂分子合成所驱动的.
- 生物测试,化学生物学和数据科学的整合为该领域提供了新的机会.
结论:
- 由于化学生物学和数据科学的进步,天然产品合成有望复苏.
- 有机化学的未来在于合成和生物学的交叉点.
- 持续的社区支持对于促进自然产品合成的创新至关重要.
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