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双极性疾病中的炎症生物标志物,认知功能和脑成像异常:系统性审查
Altamura Mario1, Leccisotti Ivana1, Mollica Anita1
1Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Clinical neuropsychiatry
|April 1, 2024
概括
神经炎症与双相情感障碍 (BD) 的认知障碍有关. 关键的炎症标志物如CRP和细胞因子与BD患者的认知缺陷和大脑变化相关,这表明潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 情绪障碍,包括双相情绪障碍 (BD),越来越多地与神经炎症有关.
- 神经营养不良因素也在这些疾病的病理生理学中发挥着作用.
- 了解这些联系对于开发有效的治疗方法至关重要.
研究的目的:
- 审查和评估认知障碍,脑成像异常和双相情感障碍 (BD) 中的炎症生物标志物之间的关联.
- 综合目前关于神经炎症在BD中的作用的证据.
主要方法:
- 在主要数据库 (PubMed,Scopus等) 中按照PRISMA指南进行系统的文献搜索. 在2023年8月之前.
- 包括在BD患者中检查炎症标志物,认知功能和神经成像 (MRI,DTI,fMRI) 的人类临床研究.
- 对调查炎症标志物对大脑变化的缓解作用的研究进行分析.
主要成果:
- 包括59项研究,表明外周炎症标志物 (CRP,IL-1RA,IL-6,TNF-α) 与BD中的认知障碍之间存在强烈联系.
- 有证据表明,神经炎症有助于 BD 的认知缺陷和大脑结构/功能异常.
- 特定的炎症生物标志物显示出强有力的关联,而其他生物标志物则缺乏令人信服的证据.
结论:
- 在BD中,认知障碍与神经炎症显著相关.
- 系统性炎症可能会导致影响BD认知的大脑结构的恶化.
- 识别特定的炎症标志物可能有助于BD的早期治疗干预.
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