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在遗传性血管中COVID-19和疫苗接种:单一中心体验单一中心体验
Öner Özdemir1, Ümmügülsüm Dikici1
1Division of Allergy and Immunology, Department of Pediatrics, Sakarya University Faculty of Medicine, Research and Training Hospital of Sakarya University, Sakarya, Türkiye.
The World Allergy Organization journal
|April 1, 2024
概括
遗传性血管 (HAE) 患者可以安全地接种COVID-19疫苗,包括非活化和mRNA类型. 在这项研究中,SARS-CoV-2感染并没有持续恶化HAE攻击.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
- 传染性疾病 传染性疾病
背景情况:
- 遗传性血管 (HAE) 是一种罕见的遗传性疾病,其特征是经常出现的发作.
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染和COVID-19疫苗接种对HAE患者的影响需要调查.
研究的目的:
- 评估SARS-CoV-2感染和COVID-19疫苗接种对HAE患者的影响.
- 评估疫苗接种或感染后HAE发作的安全性和潜在恶化.
主要方法:
- 对10名HAE患者 (3名男性,7名女性) 的回顾性评估,年龄在12-66岁之间.
- 分析与COVID-19感染和疫苗接种状态相关的HAE攻击频率和严重程度.
- 包括1型和2型HAE患者.
主要成果:
- 两名HAE患者在COVID-19疾病期间经历了血管发作.
- 六名HAE患者接受了多剂量COVID-19疫苗 (无活化和mRNA).
- 在接种疫苗期间或接种疫苗后,在接种疫苗后长达一年内,没有观察到HAE发作的增加.
结论:
- 无活化和mRNACOVID-19疫苗对于HAE患者似乎是安全的.
- SARS-CoV-2 感染并不总是与 HAE 恶化有关.
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