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高危肝细胞癌:肝动脉输液化疗与跨动脉化学栓塞

Baogen Zhang¹, Biqing Huang², Fan Yang³

¹Department of Oncology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, 101149, People's Republic of China.

Journal of hepatocellular carcinoma

|April 1, 2024

概括

肝动脉输液化疗 (HAIC) 与跨动脉化学栓塞 (TACE) 相比,为高风险的肝细胞癌 (hHCC) 提供更好的疾病控制,具有类似的长期存活率和安全性.

科学领域:

肝胆道医学肝胆道医学
干预性瘤学干预性瘤学
癌症治疗方法癌症治疗方法

背景情况:

高风险的肝细胞癌 (hHCC) 存在重大治疗挑战.
动脉内治疗对于管理hHCC至关重要.
对比肝动脉输液化疗 (HAIC) 和跨动脉化学栓塞 (TACE) 对于优化患者的治疗结果至关重要.

研究的目的:

为了比较HAIC与TACE在hHCC患者中的疗效和安全性.
评估整体生存率 (OS),无进展生存率 (PFS),客观反应率 (ORR) 和转换手术率 (CSR).
评估不良事件 (AE) 并确定受益于HAIC的患者子组.

主要方法:

对接受初始动脉内治疗的1765名hHCC患者的回顾性审查.
倾向性得分匹配 (PSM) 来创建可比的TACE (n=444) 和HAIC (n=444) 组.
卡普兰-梅尔对OS和PFS的分析,与ORR,CSR和AE发病率的比较.

主要成果:

与TACE相比,HAIC的PFS中位数显著长 (6.1个月与3.3个月相比),ORR高 (24.8%与11.7%) 和CSR高 (15.5%与8.9%相比).
在两组之间,OS是可比的 (10.3个月与8.2个月).
在HAIC中,3/4级AE的发病率较低 (8.1%与23.9%相比),特别有利于大型瘤 (>10厘米) 和晚期门静脉瘤血栓瘤 (PVTT Vp4) 的患者.

结论:

与TACE相比,HAIC为hHCC患者提供了优越的疾病控制和无进展的生存期.
HAIC与可比的长期整体存活率和潜在的更好的安全性相关.
对于特定的hHCC患者亚组来说,HAIC是一种有前途的治疗选择,包括那些患有大瘤和晚期PVTT的患者.

关键词:

肝动脉输液化疗肝动脉输液化疗肝细胞癌是肝细胞癌.高风险的高风险的风险.通过动脉的化学栓塞.

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