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携带LMNA突变的灵长类模型发展为扩展性心肌病

Xiang Luo1,2,3, Hao Jia4, Fang Wang1,2

  • 1State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.

JACC. Basic to translational science
|April 1, 2024
PubMed
概括

研究人员创建了一个层状A/C (LMNA) 突变灵长类模型来研究扩展性心肌病 (LMD). 这个模型准确地复制了人类LMD表型和疾病进展,为研究提供了有价值的工具.

关键词:
通过CRISPR介导的腺基编辑.扩张性心肌病症 扩张性心肌病症层 A/C A/C 层 A/C 层 A/C 层 A/C 层灵长类动物模型模型

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