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慢性乙型肝炎和心血管疾病的门德尔随机化

Dongjie Wu¹, Feiyang Xiong², Qingzhi Ran³

¹Department of Infectious Diseases, Guang'anmen Hospital, China Academy of Chinese Medicine Sciences, Beijing, China.

Frontiers in cardiovascular medicine

|April 1, 2024

概括

慢性乙型肝炎 (CHB) 增加了动脉样硬化和冠心病的风险. 然而,CHB与缺血性中风风险降低有关,这挑战了之前的观察结果.

科学领域:

心血管流行病学心血管流行病学
肝病学肝病学是一种肝病学.
遗传学是一个遗传学.

背景情况:

观察性研究表明,慢性乙型肝炎 (CHB) 与心血管疾病 (CVD) 之间存在联系,但因果关系尚不清楚.
不一致的发现需要强大的方法来确定CHB和各种CVD之间的因果关系.

研究的目的:

使用孟德尔随机化 (MR) 调查CHB和心血管疾病之间的潜在因果关系.
检查CHB和特定心血管结果之间的关系:动脉样硬化,冠心病,高血压和缺血性中风.

主要方法:

使用两个样本的门德尔随机化 (MR) 分析.
利用全基因组关联研究 (GWAS) 的暴露 (CHB) 和终点 (CVD) 数据.
应用反变量加权 (IVW) 作为主要方法,辅以加权中位数,MR-Egger和其他MR技术.

主要成果:

对CHB的遗传敏感性与动脉样硬化 (OR=1.048,P=3.08E-04) 和冠状动脉心脏病 (OR=1.039,P=0.020) 的风险增加显著相关.
CHB显示与缺血性中风风险的反向相关性 (OR=0.972,P=4.13E-04).
在CHB和高血压之间没有发现显著的关联 (OR=1.021,P=0.121).

结论:

慢性乙型肝炎与动脉样硬化和冠心病的风险增加有关.
冠心血管疾病与缺血性中风风险降低有关,这表明与心血管结果的复杂关系.

关键词:

门德尔的随机化 (MR)动脉样硬化动脉样硬化心血管疾病心血管疾病有关因果关系的因果关系慢性乙型肝炎 (CHB) 是一种全基因组关联研究 (GWAS)缺血性中风 (IS) 是一种

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