减肥手术对卵巢储备标志物的影响及其与营养参数和阿迪波基因的相关性
Alba Andreu1,2, Lilliam Flores1,3,4, Marta Méndez5
1Obesity Group, Endocrinology and Nutrition Department, Hospital Clinic de Barcelona, Barcelona, Spain.
Frontiers in endocrinology
|April 1, 2024
概括
腹部外科手术可以降低抗穆勒尔激素 (AMH) 和卵巢储备标记物,其水平长期稳定. 手术后的AMH与雄激素和胰岛素耐药性标志物相关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢手术是一种代谢手术.
- 卵巢生理学 卵巢生理学
背景情况:
- 已知腹腔外科手术 (BS) 会导致反米勒尔激素 (AMH) 的短期减少.
- 对卵巢储备和BS后影响因素的长期影响仍未得到充分研究.
研究的目的:
- 评估空腹手术后卵巢储备标记的长期变化.
- 为了确定与AMH水平波动相关的因素,在腹腔外科手术后.
主要方法:
- 对20名接受减肥手术的女性 (18-40岁) 进行前性队列研究.
- 在手术后24-36个月进行人体测量,生殖激素,代谢参数和营养标志物的连续测量.
- 额头毛囊数 (AFC) 通过超声波评估;使用混合模型分析的纵向数据.
主要成果:
- 抗穆勒尔激素 (AMH) 水平在手术后12个月显著下降,然后稳定.
- 前毛囊数 (AFC) 在12个月后呈现非显著的下降趋势,随后稳定.
- 降低的AMH与减肥,BMI降低和增加的脂肪素相关;AMH与丸激素,自由雄激素指数,胰岛素和HOMA指数正相关.
结论:
- 腹腔外科手术导致AMH显著持续下降,并趋向于减少AFC.
- 手术后的AMH水平与雄激素状态和胰岛素抵抗有关.
- 卵巢储备标记在减肥手术后长期稳定.
相关概念视频
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
01:24Obesity
498
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
498