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神经精神病症状预测痴呆症的认知衰退速度更快 协作护理比抗精神病药物使用更快
Yen-Jen Chen1,2, Ming-Che Chang3, Kai-Ming Jhang4
1Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan.
Neuropsychiatric disease and treatment
|April 1, 2024
概括
神经精神症状 (NPS),而不是抗精神病药物,显著加快痴呆症患者的认知衰退. 早期发现和干预NPS对于管理痴呆症护理中的认知健康至关重要.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 认知能力下降是痴呆症和轻度认知障碍的一个标志.
- 神经精神症状 (NPS) 在痴呆症中很常见,影响患者的福祉和护理.
- 与抗精神病药物使用对认知衰退的NPS的影响仍然是积极研究的领域.
研究的目的:
- 为了比较NPS或抗精神病药物处方的患者和没有NPS或抗精神病药物的患者的短期认知结果.
- 确定疾病状态或治疗方式是否与更快的认知衰退有关.
- 研究个别NPS对认知衰退的具体影响.
主要方法:
- 对407名患有痴呆症或轻度认知障碍的患者前性队列的回顾性分析.
- 使用认知能力查仪器 (CASI) 进行年度认知评估.
- 多变量线性回归分析NPS,抗精神病药物使用和认知衰退之间的关联 (年度三角形CASI),调整为混因素.
主要成果:
- 神经精神症状 (NPSs),而不是抗精神病使用,与更快的认知衰退有关.
- 一个较高的基线NPI总得分显著预测了更快的CASI得分下降 (1年三角形CASI = -0.22,p=0.010).
- 包括妄想,兴奋,抑郁,焦虑,高兴和冷漠在内的特定NPS与增加的认知衰退有关.
结论:
- 某些神经精神症状,而不是抗精神病药物的使用,在痴呆症护理环境中推动了更快的认知衰退.
- 强调对痴呆症患者的NPS进行查和干预的重要性.
- 强调需要全面的护理模型,以解决痴呆症的认知和行为方面.
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