饮食炎症指数与美国成年人的代谢功能障碍相关的脂肪肝疾病有关
Jing Yan1,2, Jun Zhou1, Yuanyuan Ding1
1Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China.
Frontiers in nutrition
|April 1, 2024
概括
促炎症饮食与患有代谢功能障碍相关脂肪肝疾病 (MAFLD) 的风险更高有关. 改善饮食模式可以帮助减少MAFLD发病率.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是全球最常见的慢性肝病.
- MAFLD与代谢综合征,肥胖,脂质不良和2型糖尿病 (T2DM) 有关.
- 饮食在炎症中起着至关重要的作用,是MAFLD病变的关键因素,但对饮食和MAFLD联系的研究有限.
研究的目的:
- 通过饮食炎症指数 (DII) 评估的饮食质量与MAFLD之间的关系.
- 分析来自大量成年人群的横截面数据,以理解这种关联.
- 探索饮食与MAFLD关系中的潜在年龄特定差异.
主要方法:
- 利用了2017-2018年国家健康和营养检查调查 (NHANES) 中3633名成年人的数据.
- 使用后勤回归来分析DII得分与MAFLD流行率之间的关联.
- 进行了子组和值效应分析,以进一步阐明这种关系.
主要成果:
- 在较高的DII得分和MAFLD的几率增加 (OR=1.05) 之间观察到一个积极的关联.
- DII和MAFLD之间的联系在年龄在20-41岁的年轻人中尤为显著 (OR=1.20).
- 确定了DII和MAFLD之间的非线性,U形关系,DII=3.06.06的拐点.
结论:
- 促炎症饮食与发展MAFLD的更高风险有关.
- 饮食模式是MAFLD预防和管理的可修改的生活方式因素.
- 有针对性的饮食干预措施可能至关重要,尤其对年轻人群有风险.
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