乳二烯降低了自我乳化药物输送系统中的表面活性剂含量
Harish Khairnar1, Sanya Jain1, Bappaditya Chatterjee2
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, Mumbai 400056, India.
ACS omega
|April 1, 2024
概括
作为一种天然乳化剂的乳酸,成功地降低了烯酸纤维酸自乳化药物输送系统 (SEDDS) 中的合成表面活性剂含量. 这种含有乳酸的SEDDS配方显著提高了大鼠的口服生物可用性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 生物材料是一种生物材料.
背景情况:
- 自乳化药物递送系统 (SEDDS) 提高了难溶药物的口服生物可用性.
- 高合成表面活性剂含量给SEDDS配方带来了挑战.
- 乳酸具有作为天然乳化剂的潜力,可以降低合成表面活性剂的负载.
研究的目的:
- 开发一种使用乳二来降低合成表面活性剂含量的纤维酸SEDDS.
- 评估乳二改性SEDDS的物理化学特性和体外药物释放.
- 评估新型SEDDS配方的体内口服药理学性能.
主要方法:
- 纤维酸SEDDS的配方,含有或不含有乳酸铁素,含有Tween的不同含量.
- 热力学稳定性,泽塔潜力,药物含量和传导分析.
- 在实验室中对固化SEDDS的药物释放研究和大鼠的药物动力学评估.
主要成果:
- 与传统的SEDDS (30%) 相比,含有乳酸的SEDDS (FEN Lf-SEDDS) 的Tween含量降低了21%.
- 这两种配方均表现出热力学稳定性,相似的泽塔电位,药物含量和传导性.
- 在大鼠模型中,FEN Lf-SEDDS显著改善了口服生物可用性 (1.3-5.5倍高).
结论:
- 乳二可以有效地替代SEDDS中的合成表面活性剂,将Tween含量减少27%,同时保持相似的物理化学特性.
- 开发的乳二改性SEDDS提供了对纤维酸的增强口服生物可用性.
- 这种方法为开发更安全,更有效的口服药物输送系统提供了一个有希望的战略.
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