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Updated: Jun 29, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Published on: February 9, 2021

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小说 2-阿米诺佐衍生物:作为抗癌剂的对接,合成和生物评估

Omar M Salih1, Mahmoud A Al-Sha'er1, Haneen A Basheer2

  • 1Pharmaceutical Sciences Department, College of Pharmacy, Zarqa University, Zarqa 13132, Jordan.

ACS omega
|April 1, 2024
PubMed
概括

新的2-aminobenzothiazole化合物 (OMS5,OMS14) 对肺癌和乳腺癌细胞系表现出强大的抗癌活性. 虽然它们不仅仅依赖PI3Kγ抑制,但它们的机制涉及影响关键信号通路,如PIK3CD/PIK3R1.

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