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超声波辅助醇衍生物的绿色生物催化剂:合成,抗菌评估和对接分析

Ahmed M Hussein^1,2, Sobhi M Gomha³, Nahed A Abd El-Ghany⁴

¹Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.

|April 1, 2024

概括

基托桑船船公司

科学领域:

绿色化学绿色化学
有机合成有机合成
生物催化剂是一种生物催化剂.

背景情况:

酸盐 (Cs) 是一种具有催化潜力的天然聚合物.
接种Cs增强了其用于催化应用的特性.

研究的目的:

开发一种环保的生物催化剂,用于合成新型醇衍生物.
为了研究甲基化物Cs Schiff的基液凝 (TCsSB) 的催化效率.

主要方法:

合成TCsSB水凝的合成.
使用TCsSB.B.进行超声波辅助的提亚衍生物合成.
使用光谱方法 (IR,NMR,MS) 的结构阐明.
对抗菌活性和分子对接研究的评估.

主要成果:

与 Cs.相比,TCsSB 显示出更高的表面积和热稳定性.
有高产量的新型 thiazole 衍生物的高效合成.
在没有显著的催化活性损失的情况下,TCsSB显示了可重复使用性.
合成的化合物在体外表现出有前途的抗菌活性和在中有利的ADME特性.

结论:

TCsSB是一种有效且可重复使用的环保生物催化剂,用于提亚合成.
开发的方法提供了温和的条件,快速的反应和高产量.
新型醇衍生物显示出抗菌应用的潜力.

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